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Mir-6 microRNA precursor : ウィキペディア英語版 | Mir-6 microRNA precursor
The mir-6 microRNA precursor is a precursor microRNA specific to Drosophila species. In ''Drosophila melanogaster'' there are three mir-6 paralogs called dme-mir-6-1, dme-mir-6-2, dme-mir-6-3, which are clustered together in the genome. The extents of these hairpin precursors are estimated based on hairpin prediction. Each precursor is generated following the cleavage of a longer primary transcript in the nucleus, and is exported in the cytoplasm. In the cytoplasm, precursors are further processed by the enzyme Dicer, generating ~22 nucleotide products from each arm of the hairpin. The products generated from the 3' arm of each mir-6 precursor have identical sequences. Both 5' and 3' mature products are experimentally validated. Experimental data suggests that the mature products of mir-6 hairpins are expressed in the early embryo of ''Drosophila'' and target apoptotic genes such as ''hid'', ''grim'' and ''rpr''. ==Links to further miRNAs== Near perfect complementarity has been observed between miR-5 and miR-6 at 20/21 nucleotides. However, miR-5 is only related on a minor level to any of the three respective miR-6 sequences. miR-6 genes reside in a gene cluster containing other non-K-box family miRNAs, including miRNAs-3 and-309, and the Brd box family gene ''mir-4''. Alignment has shown miR-6 to share the same family motif as miR-11 and miR-2b, together making up the mir-2 clan. There is, however, little similarity in the 3' ends between these clan members.
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